The impact of interval vs. continuous training on troponin and natriuretic peptide levels in post-myocardial patients: a randomised control trial

Abstract Introduction High-intensity interval training (HIIT) and moderate-intensity continuous (MICT) are two well established used exercise modalities for cardiac rehabilitation in patients after myocardial infarction. However, data on their effects clinically relevant biomarkers, e.g. troponin N-terminal pro-brain natriuretic peptide (NT-proBNP) levels scarce. The aim of the study was to assess acute long-term HIIT vs. MICT NT-proBNP Methods Patients referred infarction were randomised either or MICT. consisted 7 cycles 1.5 min 80–90% VO2peak 3 65–70% intensity; 32 75% intensity. We have determined before (resting), immediately after, one hour (a) first (b) last session, order appraise specific an response training. Cardiopulmonary testing performed all patients. Wilcoxon signed-rank test compare related samples. Results One hundred six included (55±10 years age, 20% females), 53 each group. There no differences between groups baseline characteristics. Both caused release during session (from median 159 169 ng/L, p<0.001 HIIT; from 217 226 MICT), while only additionally lead elevation even 1 programme 182 p=0.002). After 36 sessions programme, this trend a further increase not present. Neither nor raised both visit. types (during recovery), however, decrease level present significant, but visit 10.5 10.0 p=0.014 13.1 12.4 p=0.035 MICT). Interestingly, MICT, HIIT, significant termination 10.9 p=0.004). Conclusion significantly cause levels, is associated with On contrary, neither modality causes suggesting that safety pattern may be comparable. Funding Acknowledgement Type funding sources: None.